Words matter. These are the best David Andrew Sinclair Quotes, and they’re great for sharing with your friends.
I was criticized for saying that Pfizer doesn’t know how to make a molecule right.
I believe in my work and advocate for my conclusions.
The mice that had the resveratrol in their diet were still obese, but they were seemingly or relatively immune to the effects of the obesity. So their arteries were clear, their liver was nice and thin. Their bones were stronger. They could run further.
When I started in the field, aging research was the backwater of biology. The idea that you could find a molecule that would prevent many diseases at once was considered impossible.
We used to think that aging was a lot like, as if we were cars made fresh and youthful and then we’ve entered this breakdown in diet. What we didn’t realize until recently is that we’re much more complex than a car. We fix ourselves if we’re broken.
It’s been known since 1916 that cutting back calories is beneficial in every organism it’s been tested on – from yeast to worms to mice to monkeys. I think it would be a surprise if we are an exception to that rule.
If I’m not hungry and I’m busy, I am quite happy to skip a meal. It’s informal intermittent fasting. I feel strongly that this is one of the strongest areas of longevity research.
I actually think it will be possible one day to be immortal.
A lot of scientists are hesitant to get involved with industry. It’s seen as, you know, getting in bed with the devil, actually. But I found that doing this has been really the only way and one of the best ways I know to take a finding from the bench side to people.
Scientists don’t like to be called salesmen.
We can change our lives for the better, and always have. We used to think pain during surgery and dying during childbirth were inevitable. We no longer accept that, and we shouldn’t just accept aging.
The ultimate goal is to have a pill that can prevent or reverse all diseases of aging. The major diseases that I’d like to tackle are heart disease, diabetes, Alzheimer’s and cancer. I want to reduce those diseases by 10 percent.
So what we’re all hoping to do, us researchers, is to develop ways to not really just extend lifespan but to keep people healthier for longer. We may just have a greater impact than a single drug because these drugs could potentially treat one disease but prevent 20 others.
Aging is just like any deterioration of the body. It fulfills every category of what we call a disease except one: it impacts more than half the population.
So aging is really just the way we deteriorate over time. Lifespan on the other hand is how long we live. We typically refer to that as longevity.
Resveratrol does not act primarily as an antioxidant. It is far more interesting and powerful than that. Resveratrol turns on our body’s genetic defenses against diseases and aging itself.
Unfortunately, because aging is so common and natural, we tend to think of it as destiny or something we should accept.
I’m driven to get to goals as fast as possible. It frustrates people in my lab who have something they think is cool, but if it doesn’t move us forward, I don’t want to do it.
Well, we can study aging in people, but of course those studies take decades. So what we try to do is we use simpler organisms to try and understand the basic mechanisms and so in my laboratory, for example, we use things like simple baker’s yeast that we use to make bread.
